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The Quantum of the Seas was the biggest ship to date the yard had to build In MEYER TURKU delivered Mein Schiff 3 to TUI Cruises, built in Germany, which was completed at record speed in merely 20 months.
Glandular epithelial cells differentiate into complex multicellular or acinar structures, when embedded in three-dimensional 3D extracellular matrix. The spectrum of different multicellular morphologies formed in 3D is a sensitive indicator for the differentiation potential of normal, non-transformed cells compared to different stages of malignant progression. In addition, single cells or cell aggregates may actively invade the matrix, utilizing epithelial, mesenchymal or mixed modes of motility.
Dynamic phenotypic changes involved in 3D tumor cell invasion are sensitive to specific small-molecule inhibitors that target the actin cytoskeleton. We have used a panel of inhibitors to demonstrate the power of automated image analysis as a phenotypic or morphometric readout in cell-based assays. We introduce a streamlined stand-alone software solution that supports large-scale high-content screens, based on complex and organotypic cultures.
AMIDA A utomated M orphometric I mage D ata A nalysis allows quantitative measurements of large numbers of images and structures, with a multitude of different spheroid shapes, sizes, and textures. AMIDA supports an automated workflow, and can be combined with quality control and statistical tools for data interpretation and visualization. We have used a representative panel of 12 prostate and breast cancer lines that display a broad spectrum of different spheroid morphologies and modes of invasion, challenged by a library of 19 direct or indirect modulators of the actin cytoskeleton which induce systematic changes in spheroid morphology and differentiation versus invasion.
These results were independently validated by 2D proliferation, apoptosis and cell motility assays. We identified three drugs that primarily attenuated the invasion and formation of invasive processes in 3D, without affecting proliferation or apoptosis. Our approach supports the growing needs for user-friendly, straightforward solutions that facilitate large-scale, cell-based 3D assays in basic research, drug discovery, and target validation.
This is an open-access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This study was funded by a grant from Academy of Finland, Grant
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Eliminating medicine waste in a Finnish university hospital — a qualitative study
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Turku, Finland, October 22nd, Forendo Pharma today announced the successful closing of a EUR 12 million new investment round. FP inhibits the enzyme beta-hydroxysteroid dehydrogenase 1 HSD17B1 —and is a novel drug with potential to become the first specific treatment for endometriosis through its organ specific regulation of estrogen hormone activity. Forendo will also progress early phase programs from its HSD platform for other hormone dependent diseases.
There is a large unmet medical need as the current available therapies are unspecific, focusing on pain medication, hormonal treatments, and surgery, leaving many patients without satisfactory relief of their chronic pelvic pain either because of poor efficacy or poor tolerability. The total annual societal cost of endometriosis in Europe and the USA is estimated to be beyond billion Euros.
These important international investors will significantly expand our network of experts and potential partners from the main markets to secure our success with this new invention. The key programs are HSD17B1 enzyme inhibitor , FP, aimed for a novel specific treatment of endometriosis and fispemifene, a program with positive Phase II data in treatment of secondary hypogonadism and with disease model data in lower urinary tract symptoms and chronic prostatitis.
Forendo has recently signed a licensing agreement for fispemifene development and marketing in USA with Apricus Biosciences Inc www. The core team of Forendo includes pioneers within Finnish drug development and leading academic professionals in endocrinology. Further information can be found through the links below www.